Mario Otto, MD, PhD close
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Mario Otto, MD, PhD  

Mario Otto, MD, PhD Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

Specialties

Pediatric Hematology and Oncology

UW Health Clinics

American Family Children's Hospital
(608) 263-6420 | (800) 323-8942 | Map
American Family Children's Hospital
(608) 263-6420 | (800) 323-8942 | Map

Hospital Affiliation(s)

American Family Children's Hospital (primary)

Languages Spoken

English, German
Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.

UW School of Medicine and Public Health

Department of Pediatrics

Professional Certifications and Education

Board Certification Pediatrics
Pediatric Hematology-Oncology
Fellowship St. Jude Children's Research Hospital, Memphis, TN
Residency Children's University Hospital, Tuebingen, Germany
Akron Children's Hospital, Akron, OH
Internship Children's University Hospital, Tuebingen, Germany
Medical School University of Tuebingen School of Medicine, Germany, 1995

Procedures

Our doctors provide a wide range of services. The following list represents some, but not all, of the procedures offered by this physician.

Programs & Conditions

Research

Dr. Otto is pursuing novel, alternative approaches to treat childhood cancer. His research includes areas such as adoptive immunotherapies, nano-oncology and stem cell graft design for the transplant setting.


PubMed Articles
Navid F Sondel PM Barfield R Shulkin BL Kaufman RA Allay JA Gan J Hutson P Seo S Kim K Goldberg J Hank JA Billups CA Wu J Furman WL McGregor LM Otto M Gillies SD Handgretinger R Santana VM . Phase I trial of a novel anti-GD2 monoclonal antibody, Hu14.18K322A, designed to decrease toxicity in children with refractory or recurrent neuroblastoma. J Clin Oncol. 2014 May 10;32(14):1445-52
[PubMed ID: 24711551]
Baiu DC Brazel CS Bao Y Otto M . Interactions of iron oxide nanoparticles with the immune system: challenges and opportunities for their use in nano-oncology. Curr Pharm Des. 2013;19(37):6606-21
[PubMed ID: 23621531]
Otto M Shulkin BL Kundu M Sandlund JT Snyder SE Metzger ML . Histiocyte-rich xanthomatous pseudotumor mimicking relapse on positron emission tomography imaging in an adolescent with primary mediastinal diffuse large B-cell lymphoma. J Pediatr Hematol Oncol. 2012 Apr;34(3):232-5
[PubMed ID: 22082744]
Jiao P Zhou H Otto M Mu Q Li L Su G Zhang Y Butch ER Snyder SE Jiang G Yan B . Leading neuroblastoma cells to die by multiple premeditated attacks from a multifunctionalized nanoconstruct. J Am Chem Soc. 2011 Sep 7;133(35):13918-21
[PubMed ID: 21827210]
Sorkin LS Otto M Baldwin WM 3rd Vail E Gillies SD Handgretinger R Barfield RC Ming Yu H Yu AL . Anti-GD(2) with an FC point mutation reduces complement fixation and decreases antibody-induced allodynia. Pain. 2010 Apr;149(1):135-42
[PubMed ID: 20171010]
Barfield R Chen X Otto M Handgretinger R . Beyond the FACS. Stem Cells. 2007 Nov;25(11):2972
[PubMed ID: 17656640]
Otto M Chen X Martin WJ Leung W Knowles J Holladay M Houston J Handgretinger R Barfield RC . Selection of stem cells by using antibodies that target different CD34 epitopes yields different patterns of T-cell differentiation. Stem Cells. 2007 Feb;25(2):537-42
[PubMed ID: 17023516]
Otto M Barfield RC Martin WJ Iyengar R Leung W Leimig T Chaleff S Gillies SD Handgretinger R . Combination immunotherapy with clinical-scale enriched human gammadelta T cells, hu14.18 antibody, and the immunocytokine Fc-IL7 in disseminated neuroblastoma. Clin Cancer Res. 2005 Dec 1;11(23):8486-91
[PubMed ID: 16322312]
Chen X Barfield R Benaim E Leung W Knowles J Lawrence D Otto M Shurtleff SA Neale GA Behm FG Turner V Handgretinger R . Prediction of T-cell reconstitution by assessment of T-cell receptor excision circle before allogeneic hematopoietic stem cell transplantation in pediatric patients. Blood. 2005 Jan 15;105(2):886-93
[PubMed ID: 15358630]
Otto M Barfield RC Iyengar R Gatewood J Müller I Holladay MS Houston J Leung W Handgretinger R . Human gammadelta T cells from G-CSF-mobilized donors retain strong tumoricidal activity and produce immunomodulatory cytokines after clinical-scale isolation. J Immunother. 2005 Jan-Feb;28(1):73-8
[PubMed ID: 15614047]
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