J. Carter Ralphe, MD  
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J. Carter Ralphe, MD Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

Dr. J. Carter Ralphe is the chief of the Division of Pediatric Cardiology within the UW School of Medicine and Public Health and co-director of UW Health's Pediatric Heart Program. He is board certified in pediatric cardiology. Dr. Ralphe and Chief Pediatric Cardiothoracic Surgeon Petros Anagnostopoulos, MD, lead the comprehensive Pediatric Heart Program at American Family Children's Hospital. Dr. Ralphe’s clinical interests include diagnosis and treatment of congenital heart defects, acquired and familial forms of cardiomyopathy and pediatric heart failure.


Pediatric Cardiovascular Medicine

Pediatric Heart Care


American Family Children's Hospital
(608) 263-6420 | (800) 323-8942 | Map
Aurora Children's Health (Oshkosh)
(920) 303-8700 | | Map
Southwest Health Center
(608) 342-5060 | | Map

UW School of Medicine and Public Health

Department of Pediatrics

Professional Certifications and Education

Board Certification Pediatric Cardiology
Fellowship University of Iowa Hospitals and Clinics, Iowa City, IA
Residency University of Iowa Hospitals and Clinics, Iowa City, IA
Internship University of Iowa Hospitals and Clinics, Iowa City, IA
Medical School State University of New York, Brooklyn, NY

Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.

Dr. Ralphe's research interests include genetic forms of cardiomyopathy and the development of stem cell models to study human heart disease.

PubMed Articles
de Lange WJ Farrell ET Kreitzer CR Jacobs DR Lang D Glukhov AV Ralphe JC Human iPSC-engineered cardiac tissue platform faithfully models important cardiac physiology. Am J Physiol Heart Circ Physiol . 2021 Apr 1;320(4):H1670-H1686
[PubMed ID: 33606581]
Pewowaruk RJ Barton GP Johnson C Ralphe JC Francois CJ Lamers L Roldán-Alzate A Stent interventions for pulmonary artery stenosis improve bi-ventricular flow efficiency in a swine model. J Cardiovasc Magn Reson . 2021 Feb 25;23(1):13
[PubMed ID: 33627121]
Melby JA de Lange WJ Zhang J Roberts DS Mitchell SD Tucholski T Kim G Kyrvasilis A McIlwain SJ Kamp TJ Ralphe JC Ge Y Functionally Integrated Top-Down Proteomics for Standardized Assessment of Human Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissues. J Proteome Res . 2021 Feb 5;20(2):1424-1433
[PubMed ID: 33395532]
Pewowaruk R Hermsen J Johnson C Erdmann A Pettit K Aesif S Ralphe JC Francois CJ Roldán-Alzate A Lamers L Pulmonary artery and lung parenchymal growth following early versus delayed stent interventions in a swine pulmonary artery stenosis model. Catheter Cardiovasc Interv . 2020 Dec;96(7):1454-1464
[PubMed ID: 33063918]
Tucholski T Cai W Gregorich ZR Bayne EF Mitchell SD McIlwain SJ de Lange WJ Wrobbel M Karp H Hite Z Vikhorev PG Marston SB Lal S Li A Dos Remedios C Kohmoto T Hermsen J Ralphe JC Kamp TJ Moss RL Ge Y Distinct hypertrophic cardiomyopathy genotypes result in convergent sarcomeric proteoform profiles revealed by top-down proteomics. Proc Natl Acad Sci U S A . 2020 Oct 6;117(40):24691-24700
[PubMed ID: 32968017]
Anagnostopoulos PV Ralphe JC Greenberg C Commentary: Regionalization of Congenital Heart Care in the United States: Small Improvements in Outcomes-But at What Expense? Semin Thorac Cardiovasc Surg . 2020 Spring;32(1):138-139
[PubMed ID: 31628994]
Lushaj EB Bartlett HL Lamers LJ Arndt S Hermsen J Ralphe JC Anagnostopoulos PV Technical Performance Score Predicts Perioperative Outcomes in Complex Congenital Heart Surgery Performed in a Small-to-Medium-Volume Program. Pediatr Cardiol . 2020 Jan;41(1):88-93
[PubMed ID: 31676956]
Cai W Zhang J de Lange WJ Gregorich ZR Karp H Farrell ET Mitchell SD Tucholski T Lin Z Biermann M McIlwain SJ Ralphe JC Kamp TJ Ge Y An Unbiased Proteomics Method to Assess the Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes. Circ Res . 2019 Nov 8;125(11):936-953
[PubMed ID: 31573406]
Yang KC Breitbart A De Lange WJ Hofsteen P Futakuchi-Tsuchida A Xu J Schopf C Razumova MV Jiao A Boucek R Pabon L Reinecke H Kim DH Ralphe JC Regnier M Murry CE Novel Adult-Onset Systolic Cardiomyopathy Due to MYH7 E848G Mutation in Patient-Derived Induced Pluripotent Stem Cells. JACC Basic Transl Sci . 2018 Dec;3(6):728-740
[PubMed ID: 30623132]
Zawacki A Dodge A Eickhoff J Sun W Marriott E Ralphe JC Peterson AL Novel Lipid Thresholds for Screening Predict the Need for Pharmacotherapy. J Pediatr . 2018 Nov;202:220-225.e2
[PubMed ID: 30172432]
Farrell E Armstrong AE Grimes AC Naya FJ de Lange WJ Ralphe JC Transcriptome Analysis of Cardiac Hypertrophic Growth in <i>MYBPC3</i>-Null Mice Suggests Early Responders in Hypertrophic Remodeling. Front Physiol . 2018;9:1442
[PubMed ID: 30410445]
Smelter DF de Lange WJ Cai W Ge Y Ralphe JC The HCM-linked W792R mutation in cardiac myosin-binding protein C reduces C6 FnIII domain stability. Am J Physiol Heart Circ Physiol . 2018 Jun 1;314(6):H1179-H1191
[PubMed ID: 29451820]
Zawacki AW Dodge A Woo KM Ralphe JC Peterson AL In pediatric familial hypercholesterolemia, lipoprotein(a) is more predictive than LDL-C for early onset of cardiovascular disease in family members. J Clin Lipidol . 2018 Nov - Dec;12(6):1445-1451
[PubMed ID: 30150142]
Kriegel AJ Gartz M Afzal MZ de Lange WJ Ralphe JC Strande JL Molecular Approaches in HFpEF: MicroRNAs and iPSC-Derived Cardiomyocytes. J Cardiovasc Transl Res . 2017 Jun;10(3):295-304
[PubMed ID: 28032312]
Fagbuyi DB Venkataraman S Ralphe JC Zuckerbraun NS Pitetti RD Lin Y Jeong K Saladino RA Manole MD Diastolic Hypotension, Troponin Elevation, and Electrocardiographic Changes Associated With the Management of Moderate to Severe Asthma in Children. Acad Emerg Med . 2016 Jul;23(7):816-22
[PubMed ID: 27129445]
Moss RL Fitzsimons DP Ralphe JC Cardiac MyBP-C regulates the rate and force of contraction in mammalian myocardium. Circ Res . 2015 Jan 2;116(1):183-92
[PubMed ID: 25552695]
De Lange WJ Grimes AC Hegge LF Spring AM Brost TM Ralphe JC E258K HCM-causing mutation in cardiac MyBP-C reduces contractile force and accelerates twitch kinetics by disrupting the cMyBP-C and myosin S2 interaction. J Gen Physiol . 2013 Sep;142(3):241-55
[PubMed ID: 23980194]
Ralphe JC de Lange WJ 3D engineered cardiac tissue models of human heart disease: learning more from our mice. Trends Cardiovasc Med . 2013 Feb;23(2):27-32
[PubMed ID: 23295081]
Egan KR Ralphe JC Weinhaus L Maginot KR Just sinus bradycardia or something more serious? Case Rep Pediatr . 2013;2013:736164
[PubMed ID: 23476865]
de Lange WJ Grimes AC Hegge LF Ralphe JC Ablation of cardiac myosin-binding protein-C accelerates contractile kinetics in engineered cardiac tissue. J Gen Physiol . 2013 Jan;141(1):73-84
[PubMed ID: 23277475]
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