Pediatric Pulmonary Hypertension Research
Pulmonary hypertension specialists at American Family Children's Hospital are conducting important research to determine the causes and investigate the most effective courses of treatment for the disease.
Goss Laboratory: Dr. Kara Goss research is focused on the long term effects of prematurity and postnatal oxygen exposure on the cardiopulmonary unit, with a specific interest in the acute and chronic adaptive responses of the right ventricle and pulmonary vasculature following prematurity.
Eldridge Laboratory: The Eldridge laboratory investigates cardiopulmonary interactions in congenital and acquired lung disease including congenital diaphragmatic hernia, bronchopulmonary dysplasia, asthma, hepatopulmonary syndrome and, bronchiolitis obliterans.
Balasubramaniam Laboratory: The focus of the Balasubramaniam Laboratory research is the treatment and prevention of lung disease that is the result of premature birth, including abnormal lung function from premature birth and bronchopulmonary dysplasia (BPD).
McCulley Research Group: As a neonatologist Dr. David McCulley cares for many infants born prematurely with lung or pulmonary vascular development, and there are few effective treatments that improve lung function in our young patients.The goal of Dr. McCulley's research program is to identify the genetics of pulmonary vascular development and study interactions between the developing vascular system and the alveoli of the lung.
Alveologenesis in Mouse Lung: use a three-dimensional (3D) approach to examine the structural architecture and cellular composition of myofibroblasts, alveolar type 2 cells, elastin and lipid droplets in normal as well as BPD-like mouse lung.
The Pulmonary Mesenchyme Directs Lung Development: This review highlights recent research focusing on the mesenchyme that has revealed genetic and epigenetic mechanisms of its development in the context of other cell layers during respiratory lineage specification, branching morphogenesis, epithelial differentiation, lineage distinction, vascular development, and alveolar maturation.